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Donor-egg IVF/ICSI program , Bulgaria

EUR 6700 / BGN 13104

Donor-egg IVF/ICSI in Nadezhda Women’s Health Hospital

International patients applying for the donor-egg IVF/ICSI program at Nadezhda Women’s Health Hospital are taken care of personally by Dr Georgi Stamenov, head of the fertility team. This includes all consultations and ultrasound scans, assigning and monitoring the stimulation of your egg donor, egg retrieval for your egg donor and your embryo transfer.

The donor-egg IVF program at Nadezhda Hospital is with fresh eggs. Egg donors are healthy women between 22 and 34 years of age who have already had a child. They are not fertility patients, but pass a controlled ovarian stimulation just to donate their eggs.

Egg donation in Bulgaria is anonymous. You choose a donor based on a profile containing donor’s phenotype characteristics, also data about her education, job and interests.

You apply to Nadezhda Hospital’s egg-donation program by filling in the medical forms of Nadezhda, also sending us any fertility files that you have available. Then you come for a day for initial consultation and examination - preferably on day 10-12 of your period. If you don’t have a period, you can come any time you can arrange your trip. At the initial consultation Dr Stamenov will discuss your condition and chances to get pregnant; he will prescribe you medications needed to assure the optimal development of your endometrium prior to embryo transfer; if needed, you’ll be recommended additional diagnostics or treatments.

In order to achieve fresh egg donation, your cycle is synchronized with the stimulation of a suitable egg donor. Your endometrium is prepared with estradiol pills or patches by the time of your donor’s egg retrieval day. You have to be here for an ultrasound scan around day 9-11 of the beginning of the estradiol intake. For some cases the prescribed estradiol dose is adjusted or some other medications and therapies are applied in order to enhance endometrium growth and receptivity. You need to stay around 8-10 days in Bulgaria in order to complete the IVF procedure.

In the evening of your donor’s egg retrieval day you start administering also progesterone vaginally.
On the same day the eggs of your donor are fertilized with your partner’s sperm. In most cases egg fertilization in Nadezhda is done with ICSI to maximize success rate. If there are serious issues with your partner’s sperm, like low motility, poor morphology, high DNA fragmentation and low count, he may be advised to consider some further sperm selection procedures like sperm enrichment, magnetic activated cell sorting (MACS) and IMSI.

If you need donor sperm, you can easily choose an anonymous donor from Nadezhda Hospital’s sperm bank. Alternatively, on your request, it can be arranged for a frozen sperm specimen to be shipped to Nadezhda Hospital from a European sperm bank of your choice. Nadezhda works on a regular basis with Cryos.

You will be informed on a daily basis about the development of your embryos. Usually in Nadezhda embryologists try to culture your embryos by day 5 when the most viable of them reach blastocyst stage. Blastocysts are quite strong and stable. Also day 5 is most suitable for embryo transfer as usually at this time the embryo normally reaches the uterus and is ready to implant. Please, have in mind that not all embryos are considered capable of reaching blastocyst stage, so your embryo transfer may be carried out also on day 2, 3 or 4 following fertilization.

The number of embryos to be transferred is recommended individually depending mainly on the quality of the embryos, patient’s age, previous IVF fails. Embryos with the best potential to implant in the uterus are chosen for the transfer. Having been advised of the chances and potential risks, you will have the opportunity to give an informed opinion about the number of embryos that you would like to be transferred.

Shortly before transfer, the embryos selected will pass laser assisted hatching (a standard procedure at Nadezhda Hospital) in order to improve their chances for implantation.

The appropriate number of embryos is transferred to your uterus using ultrasound guidance for best placement. The procedure is painless and is carried out with great care while you are listening to some pleasant and relaxing music.

After embryo transfer you’ll be recommended two days bed rest to facilitate embryo implantation. Then you can travel back home.

Following the embryo transfer, you may be prescribed further medications for post IVF luteal phase support. You will receive a detailed e-mail by MEDSPA on how to administer all the medicines and the duration of intake for each of them. You can buy all the medicines in Bulgaria or purchase an initial quantity by the time you pregnancy is confirmed, and then supply the rest of the medicines with prescription by your GP or gynecologist in charge.

If there are embryos left after your transfer, they can be vitrified and used in a frozen embryo transfer in the future.

For more details, pls., visit

To apply for fertility treatment or ask any questions, please contact:
Mrs Iva Stoykova, Fertility Case Coordinator at e-mail:, phone: +359 885 272738, +359 889 340686

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